Latest Updates on CRISPR-cas Technology

Sickled and other red blood cells Credit: UCL Medical School

CRISPR gene editing reveals new therapeutic approach for sickle cell disease

An international team of scientists led by researchers at St. Jude Children’s Research Hospital has found a way to use CRISPR gene editing to help fix sickle cell disease and beta-thalassemia ...
RGEN-induced ‘digenome’ sequencing to capture off-target sites. (a) Overview of Digenome-seq. Forward and reverse sequence reads are shown in pink and blue, respectively. Red triangles and vertical lines indicate cleavage positions. WT, wild type.

End of CRISPR-Cas9 controversy

Researchers hahave successfully confirmed that CRISPR-Cas9 has accurate on-target effects in human cells. There has been great interest in CRISPR-Cas9 as a tool to develop anticancer ...
crispr small molecule

CRISPR-mediated gene editing using small molecules

One of the most exciting scientific advances made in recent years is CRISPR—the ability to precisely edit the genome of cells.
This image of the Cas9 complex depicts the Cas9 protein (in light 
blue), along with its guide RNA (yellow), and target DNA (red). 
Image courtesy of Bang Wong, from source material provided by 
Feng Zhang.

Broad Institute, Harvard, and MIT license CRISPR-Cas9 technology to Editas

The Broad Institute, Harvard University, the Massachusetts Institute of Technology and Editas Medicine have entered into a
Screen Shot 2015-01-02 at 9.38.31 PM

Guide-Seq: Genome-wide off-target cleavage sites of CRISPR-Cas nucleases

Massachusetts General Hospital (MGH) investigators have developed a method of detecting, across the entire genome of human
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New way to turn genes on using CRISPR-Cas9

Using a gene-editing system originally developed to delete specific genes, MIT researchers have now shown that they can
This image shows fluorescence visualization of a gill in a frog embryo using the PITCh knock-in system. The arrow indicates the gill (green). Image Credit:
Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University

A novel technique for gene insertion by genome editing

Using a novel gene knock-in technique, effective insertion of an exogenous gene was demonstrated in human cells and in animal
DMD crispr

iPS cells used to correct genetic mutations that cause muscular dystrophy

Researchers at the Center for iPS Cell Research and Application (CiRA), Kyoto University, show that induced pluripotent stem

Harvard researchers genetically ‘edit’ human blood stem cells

Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General (MGH) and Boston Children’s hospitals (BCH) for the first time have used a

Poly peak parser: Tool to identify indels from Sanger sequencing data

Prof H. Joseph Yost’s lab developed a software called Poly peak parser for identification of unknown indels using sanger sequencing of polymerase chain reaction products.This ...
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